Synthesis of (R) and (S) enantiomers of
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Abdallah Hamzé; Jean-François Hernandez; Jean Martinez
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Article
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2003
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Elsevier Science
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French
⚖ 114 KB
Fmoc-(R)-b -HomoAsp(OtBu)-OH was used for the synthesis of both (R) and (S) enantiomers of various Fmoc-protected 3-substituted 1,2,4-oxadiazole-containing b 3 -amino acids. The 1,2,4-oxadiazole heterocycle was formed using sodium acetate, a Fmoc-compatible and efficient catalyst for cyclodehydrati