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An efficient and convenient synthesis of 1,2,3-trisubstituted pyrroles via iodocyclization from ethyl acetoacetate

✍ Scribed by Xu, Pengfei; Huang, Kunzhu; Liu, Zhiguo; Zhou, Ming; Zeng, Wenbin

Book ID
120162174
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
347 KB
Volume
54
Category
Article
ISSN
0040-4039

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Dirhodium tetraacetate catalyzed decomposition of trifluoromethyl acetyl diazoacetates 6a and 6b in ethyl vinyl ether gives rise to the dihydrofuroates 7a and 7b, respectively, which can be converted into the corresponding 2-(trifluoromethyl)pyrroles. This two step pyrrole synthesis is also suitable