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An efficient and convenient multicomponent reaction for the synthesis of 2-methyl-4,6-diarylpyrimidine under solvent-free conditions

✍ Scribed by Liangce Rong; Hongxia Han; Hong Jiang; Yisi Dai; Mengjie Zhuang; Minxiang Cao; Shujiang Tu

Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 78 KB
Volume: 46
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.167

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✦ Synopsis

Abstract

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An efficient and convenient method for the preparation of 2‐methyl‐4,6‐diarylpyrimidine derivatives by the multicomponent reactions of aromatic aldehydes, aromatic ketones, and acetamidine hydrochloride in the presence of sodium hydroxide under solvent‐free conditions was reported. This method has the advantages of excellent yields, mild reaction conditions, easy workup, and environmentally friendly procedure. J. Heterocyclic Chem., (2009).

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