An Effective Strategy for the Synthesis of 6-O-(2-Amino-2-deoxy-.alpha.-D-glucopyranosyl)-D-chiro- and -D-myo-inositol 1-Phosphate Related to Putative Insulin Mimetics

Synthesis and investigation of the possi

Synthesis and investigation of the possible insulin-like activity of 1d-4-O- and 1d-6-O-(2-amino-2-deoxy-α-d-glucopyranosyl) myo-inositol 1-phosphate and 1d-6-O-(2-amino-2-deoxy-α-d-glucopyranosyl) myo-inositol 1,2-(cyclic phosphate)

✍ Amparo Zapata; Yolanda León; Jose M. Mato; Isabel Varela-Nieto; Soledad Penadés; 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 791 KB

The synthesis of the glycosyl-mya-inositol l-phosphates 1 and 2 and of the glycosyl-myoinositol 1,2-(cyclic phosphate) 3, starting from previously synthesized intermediates, is reported. Compound 3 was found to display proliferative effects on the early developing inner ear of chick embryo.