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An effective BINAP and microwave accelerated palladium-catalyzed amination of 1-chloroisoquinolines in the synthesis of new 1,3-disubstituted isoquinolines

✍ Scribed by K. Prabakaran; P. Manivel; F. Nawaz Khan

Book ID: 104097967
Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 316 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.06.045

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✦ Synopsis

A facile and microwave accelerated reaction of 1-chloro-3-(4-chlorophenyl)isoquinoline with various heterocyclic amines, catalyzed by Pd, in the presence of BINAP additive and sodium carbonate as the base, leads to the formation of 3-

Buchwald protocol in good yields. Similarly pyrazolylisoquinolines are also reported.

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