An easy access to novel steroidal dispiropyrrolidines through 1,3-dipolar cycloaddition of azomethine ylides

✍ Scribed by A.R. Suresh Babu; R. Raghunathan

• Book ID: 104095450
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 172 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.05.089

✦ Synopsis

A facile one-pot synthesis of novel steroidal dispiropyrrolidines has been accomplished by 1,3-dipolar cycloaddition reaction of various azomethine ylides derived from isatin/acenaphthenequinone/ninhydrin and sarcosine with various estrone derivatives as dipolarophiles, in good yield. The effect of various solvents on the 1,3-dipolar cycloaddition reaction are also studied.