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An asymmetric synthesis of the pentacyclic core of stemofoline

โœ Scribed by Burns, Thomas; Helliwell, Madeleine; Thomas, Eric J.


Book ID
120043420
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
575 KB
Volume
54
Category
Article
ISSN
0040-4039

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The pentacyclic base of the sponge-derived alkaloid lihouidine has been assembled from two quinoline fragments. The key step is a nitration-promoted cyclization to form the C-C bond between the two quinoline units.