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An asymmetric synthesis of (+)-morphinans in high enantiomeric purity

โœ Scribed by Meyers, A. I.; Bailey, Thomas R.


Book ID
120579637
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
519 KB
Volume
51
Category
Article
ISSN
0022-3263

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A general protocol for the synthesis of a-amino-a-alkyl phosphonic acids in either enantiomeric form is described based on the alkylation of chiral bicyclic phosphonamides derived from (R,R)and (S,S)-1,2diaminocyclohexane. 2 CSu Br(CH&Br. 2. NaN,, DMF,140% Me Y Es& 70-75% (4) 4 h., 95%. (3) 2 Y= Cl