## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An asymmetric synthesis of (−)-carbovir
✍ Scribed by Masatoshi Asami; Jun Takahashi; Seiichi Inoue
- Book ID
- 103976993
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 293 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0957-4166
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A Concise Enantioselective Pathway to Carbocyclic Nucleoside: Asymmetric Synthesis of Carbocyclic Moiety of Carbovir. -An enantioselective synthesis of cyclopentenol (VIII), an advanced intermediate for the preparation of carbovir, involving the Rh(II)-catalyzed intramolecular cyclopropanation of a
Enantioselective construction of the protected carbocycle moiety of the anti-HIV drug carbovir was achieved in 11 steps from (S)-(-)-ethyl lactate. The two key steps are a Claisen [3+3] sigmatropic rearrangement of (3S,4E)-3-(4-methoxy-phenoxymethyl)-hex-4-enoic acid dimethylamide and next, a ruthen