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An Asymmetric Synthesis of 4-Aryl-1,4-dihydropyridines

✍ Scribed by Cheng, Chen-Yu; Chen, Jy-Yih; Lee, Mei-Jing

Book ID
118123965
Publisher
Japan Institute of Heterocyclic Chemistry
Year
1996
Tongue
English
Weight
277 KB
Volume
43
Category
Article
ISSN
0385-5414

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An asymmetric synthesis of a 4-substitut
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has been achieved via a novel asymmetric Michael addition of an optically pure vinylogous amide to an a,b-unsaturated ketone. The overall process is three steps from readily available starting materials and provides an economical manufacturing route to the title compound, which was required as a can