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An asymmetric synthesis of a 4-substituted-1,4-dihydropyridine

✍ Scribed by Ian Ashworth; Phillip Hopes; Danny Levin; Ian Patel; Rashida Salloo

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
92 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

has been achieved via a novel asymmetric Michael addition of an optically pure vinylogous amide to an a,b-unsaturated ketone. The overall process is three steps from readily available starting materials and provides an economical manufacturing route to the title compound, which was required as a candidate drug for the treatment of urinary incontinence.

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