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An asymmetric dihydroxylation route to enantiomerically pure norfluoxetine and fluoxetine

✍ Scribed by Rajesh Kumar Pandey; Rodney A. Fernandes; Pradeep Kumar

Book ID
104251260
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
68 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient, practical asymmetric synthesis of (R)-norfluoxetine 1 and (R)-fluoxetine 2 has been achieved. The synthetic strategy features a Sharpless asymmetric dihydroxylation (SAD) route to the common building block 1,3-amino alcohol 9, from which (R)-norfluoxetine, (R)-fluoxetine and other related analogs can be synthesized.

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