reported identifying one missense nucleotide mutation from C to G resulting in a substitution of serine with cysteine at codon 311 in the third intracellular loop of the dopamine D2 receptor in schizophrenics. Arinami et al. 119941 reported finding a positive association between the Cys311 variant a
An association study between the Cys311 variant of dopamine D2 receptor gene and schizophrenia in the Okinawan population
β Scribed by MIZUE KANESHIMA; TSUKASA RIGA; HARUO NAKAMOTO; MASURU NAGAMINE
- Book ID
- 108961536
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 231 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1323-1316
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π SIMILAR VOLUMES
A serine-to-cysteine mutation of dopamine D2 receptor at codon 311 (Cys311) was found to have higher frequency in schizophrenic patients than in normal controls in Japanese by Arinami et al. 11994: Lancet 343: 703-7041. The Cys311 allele was found to be associated with patients with younger ageof-on
The dopamine D4 receptor is of major interest in schizophrenia research due to its high affinity for the atypical neuroleptic clozapine and a high degree of variability in the receptor gene (DRD4). Although several genetic linkage analyses performed on schizophrenia multiplex families from different