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An approach to the biomimetic synthesis of aryltetralin lignans

โœ Scribed by Andrew Pelter; Robert S. Ward; Ramohan R. Rao


Book ID
104216975
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
111 KB
Volume
24
Category
Article
ISSN
0040-4039

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Advances in the Synthesis of Aryltetrali
โœ Jonathan D. Sellars; Patrick G. Steel ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 313 KB ๐Ÿ‘ 1 views

## Abstract Etoposide and tenoposide, derivatives of the aryltetralin lignan lactone podophyllotoxin (**5**), are clinically important anticancer agents. The structure of podophyllotoxin includes four contiguous chiral centres contained within a stereochemically unstable __trans__โ€fused tetrahydron