𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An approach for cutting large and complex pedigrees for linkage analysis

✍ Scribed by Liu, Fan; Kirichenko, Anatoliy; Axenovich, Tatiana I; van Duijn, Cornelia M; Aulchenko, Yurii S


Book ID
109848840
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
395 KB
Volume
16
Category
Article
ISSN
1018-4813

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


An approach to investigating linkage for
✍ Freimer, N. B.; Reus, V. I.; Escamilla, M.; Spesny, M.; Smith, L.; Service, S.; πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 57 KB πŸ‘ 2 views

Despite the evidence that major gene effects exist for bipolar disorder (BP), efforts to map BP loci have so far been unsuccessful. A strategy for mapping BP loci is described, focused on investigation of large pedigrees from a genetically homogenous population, that of Costa Rica. This approach is

Detecting linkage for a complex disease
✍ Anita L. DeStefano; L. Adrienne Cupples; Richard H. Myers; Lindsay A. Farrer πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 34 KB

The simulated extended pedigree data of the Genetic Analysis Workshop 10 were used to examine the relationship between several quantitative traits (Q1-Q5), an environmental factor, age and sex and to identify genes contributing to the quantitative traits. A forward selection procedure was used to id

A multiple splitting approach to linkage
✍ CΓ©line Bellenguez; Carole Ober; Catherine Bourgain πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 146 KB

## Abstract Large genealogies are potentially very informative for linkage analysis. However, the software available for exact non‐parametric multipoint linkage analysis is limited with respect to the complexity of the families it can handle. A solution is to split the large pedigrees into sub‐fami