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An antisense oligonucleotide targeting the αV integrin gene inhibits adhesion and induces apoptosis in breast cancer cells

✍ Scribed by P.A. Townsend; I. Villanova; E. Uhlmann; A. Peyman; J. Knolle; R. Baron; A. Teti; M.A. Horton


Book ID
117666921
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
1016 KB
Volume
36
Category
Article
ISSN
0959-8049

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Antisense oligonucleotides targeting the
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We have constructed a series of 22 phosphorothioate 20-mer antisense oligonucleotides directed against different regions of the human (EGFR) mRNA. Treatment with EGFR antisense oligonucleotides showed a dose-dependent inhibition of human GEO colon cancer cell growth in soft agar. Western blot analys