Antisense oligonucleotides targeting the
✍
Fortunato Ciardiello; Rosa Caputo; Teresa Troiani; Gaetano Borriello; Ekambar R.
📂
Article
📅
2001
🏛
John Wiley and Sons
🌐
French
⚖ 210 KB
👁 2 views
We have constructed a series of 22 phosphorothioate 20-mer antisense oligonucleotides directed against different regions of the human (EGFR) mRNA. Treatment with EGFR antisense oligonucleotides showed a dose-dependent inhibition of human GEO colon cancer cell growth in soft agar. Western blot analys