𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An Analysis of the Composition of the Inflammatory Infiltrate in Autoimmune and Hepatitis B Virus-Induced Chronic Liver Disease

✍ Scribed by Luis Montano; Fernando Aranguibel; Margarita Boffill; Alison H. Goodall; George Janossy; Howard C. Thomas

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
524 KB
Volume
3
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

The composition of the mononuclear cell infiltrate in the liver was studied in patients with autoimmune and hepatitis B virus (HBV)-induced liver disease. The ratio of inducer to cytotoxic/suppressor cells was greater in patients with lupoid chronic active liver disease, primary biliary cirrhosis, and HBeAb positive HBV-induced chronic active liver disease than in patients with HBeAg positive HBV-induced chronic hepatitis. In patients with chronic HBV-induced (HBeAb positive) liver disease, this ratio was greater in the periportal/portal area than in the lobule. These data are consistent with a relative deficiency of the cytotoxic/suppressor population of T cells in autoimmune liver diseases and possibly in HBeAb positive HBV-induced chronic active liver disease. In the latter patients, different ratios in the periportal and centrilobular zones suggest different mechanisms for periportal and lobular hepatitis.

📜 SIMILAR VOLUMES

The phenotype of hepatitis B virus–speci
The phenotype of hepatitis B virus–specific T cells differ in the liver and blood in chronic hepatitis B virus infection
✍ J. Judy Chang; Alexander J. V. Thompson; Kumar Visvanathan; Stephen J. Kent; Pau 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 601 KB

## Hepatitis B virus (HBV)-specific T cells play a key role in clearance of the virus and in the pathogenesis of liver disease. Peripheral blood (n ‫؍‬ 25) and liver biopsies (n ‫؍‬ 19) were collected from individuals with chronic untreated HBV infection. Whole blood, cultured peripheral blood mon

Hepatitis B virus DNA patterns in the li
Hepatitis B virus DNA patterns in the liver of children with chronic hepatitis B
✍ Javier Bartolomé; Gloria Moraleda; Mercedes Ruiz Moreno; Juan Carlos Porres; Dr. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 546 KB

## Abstract The patterns of hepatitis B virus DNA (HBV‐DNA) expression were studied in 2 sequential liver biopsies from 26 children (18 treated with interferon and 8 controls) with chronic hepatitis B. In the basal biopsy replicative forms of HBV‐DNA were detected in all of the samples and integrat

Distribution of hepatitis B virus in the
Distribution of hepatitis B virus in the liver of chronic hepatitis C patients with occult hepatitis B virus infection
✍ Elena Rodríguez-Iñigo; Luisa Mariscal; Javier Bartolomé; Inmaculada Castillo; Cr 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 487 KB 👁 2 views

## Abstract Although occult hepatitis B virus (HBV) infection (HBV‐DNA in serum in the absence of hepatitis B surface antigen [HBsAg]) is common in chronic hepatitis C, its characteristics are not well known. In this work, the presence of HBV‐DNA (by polymerase chain reaction; PCR) and its distribu

Hepatitis B infection of the liver in ch
Hepatitis B infection of the liver in chronic hepatitis C without detectable hepatitis B virus DNA in serum
✍ Luisa Fernanda Mariscal; Elena Rodríguez-Iñigo; Javier Bartolomé; Inmaculada Cas 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 327 KB 👁 2 views

## Abstract Hepatitis B virus (HBV) DNA may persist in the liver in the absence of serum HBV–DNA after a self‐limited acute hepatitis B. This may also occur in patients with chronic hepatitis C virus (HCV) infection but its prevalence and its impact on liver histology is unknown. HBV–DNA was tested