In this study, peripheral-blood mononuclear cells from patients with chronic hepatitis B and spontaneous or therapy-induced disappearance of HBsAg were examined for HBV DNA. Samples were evaluated by in situ hybridization and polymerase chain reaction both before and after clearance of HBsAg. By in
Persistence of hepatitis B virus DNA in the liver after loss of HBsAg in chronic hepatitis B
β Scribed by Tse-Ling Fong; Adrian M. Di Bisceglie; Michael A. Gerber; Jeanne G. Waggoner; Jay H. Hoofnagle
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 676 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0270-9139
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π SIMILAR VOLUMES
Spontaneous loss of HBsAg is infrequent in adult HBV carriers. Little is known about this serological change in children. In a prospective study of 420 hepatitis B virus-carrier children who were observed for 1 to 12 yr (mean = 4.3 yr), spontaneous loss of HBsAg occurred in 10 patients, with an aver
## Abstract Hepatitis B virus (HBV) DNA may persist in the liver in the absence of serum HBVβDNA after a selfβlimited acute hepatitis B. This may also occur in patients with chronic hepatitis C virus (HCV) infection but its prevalence and its impact on liver histology is unknown. HBVβDNA was tested
Chronic hepatitis B virus infection is a major medical problem worldwide. Apart from HBsAg carriers, hepatitis B virus has also been identified in some HBsAg-individuals with or without antibodies to viral antigens. The molecular mechanisms underlying hepatitis B virus persistence in HBsAg-individua