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An alumina-catalyzed Michael addition of mercaptans to N-anilinomaleimides and its application to the solution-phase parallel synthesis of libraries

✍ Scribed by Soan Cheng; Daniel D Comer

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 128 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)02401-7

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✦ Synopsis

A novel strategy for the synthesis of 3-sulfanylsubstituted 1-(arylamino)-pyrrolidine-2,5-dione derivatives via the alumina-catalyzed Michael addition of mercaptans to N-anilinomaleimides is described. The utilization of alumina in the synthesis offers important advantages such as good yields, convenience and mild conditions.

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