We have developed a novel, fully automatic method for aligning the three-dimensional structures of two proteins. The basic approach is to first align the proteins' secondary structure elements and then extend the alignment to include any equivalent residues found in loops or turns. The initial secon
An Algorithm Combining DNA and Protein Alignment
✍ Scribed by Jotun Hein
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 205 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0022-5193
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✦ Synopsis
An algorithm is presented that aligns two DNA sequences minimizing the overall amount of evolution that the associated proteins have experienced. It is generalized to minimizing a weighted average of protein and DNA evolution.
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