An accurate method for the quantitation of Fmoc-derivatized solid phase supports
β Scribed by Markus Gude; Jeannine Ryf; Peter D. White
- Book ID
- 111539643
- Publisher
- Springer Netherlands
- Year
- 2002
- Tongue
- English
- Weight
- 57 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1573-3149
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An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast a
This paper describes a novel solid phase peptide synthesis method for the systematic C-terminal modification of cysteine-containing peptides. In this method, cysteine is linked to chloromethylated polystyrene resin by its thiol functionality, followed by protection of the N-terminus and derivatizati