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Amyloid β peptide oligomers directly activate NMDA receptors

✍ Scribed by Laura Texidó; Mireia Martín-Satué; Elena Alberdi; Carles Solsona; Carlos Matute


Book ID
113525904
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
606 KB
Volume
49
Category
Article
ISSN
0143-4160

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✍ Snyder, Eric M; Nong, Yi; Almeida, Claudia G; Paul, Surojit; Moran, Timothy; Cho 📂 Article 📅 2005 🏛 Nature Publishing Group 🌐 English ⚖ 365 KB

Amyloid-b peptide is elevated in the brains of patients with Alzheimer disease and is believed to be causative in the disease process. Amyloid-b reduces glutamatergic transmission and inhibits synaptic plasticity, although the underlying mechanisms are unknown. We found that application of amyloid-b