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Amyloid precursor protein binding partners in human embryonic kidney 293 cells

✍ Scribed by Ellenstein, Aviva; Abraham, Carmela R.

Book ID
122806563
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
190 KB
Volume
21
Category
Article
ISSN
0197-4580

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## Abstract The amyloid precursor protein (APP) is cleaved enzymatically by nonamyloidogenic and amyloidogenic pathways. α‐Secretase (α‐secretase), cleaves APP within the β‐amyloid (AΞ²) sequence, resulting in the release of a secreted fragment of APP (Ξ±APPs) and precluding AΞ² generation. In this st