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Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology

✍ Scribed by LIN, H.

Book ID
121279464
Publisher
The Federation of American Societies for Experimental Biology
Year
2001
Tongue
English
Weight
905 KB
Volume
15
Category
Article
ISSN
0892-6638

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## Abstract Amyloid beta protein (AΞ²)‐related death‐inducing protein (AB‐DIP) is a novel AΞ² binding protein expressed ubiquitously. Here we demonstrate that overexpression of AB‐DIP in SH‐SY5Y neuroblastoma cells causes G2/M arrest. By deletion mutant analysis, we have identified the minimal region