Amplification of the translocated c-myc genes in three Burkitt lymphoma cell lines
β Scribed by P Khaira; C.D James; M Leffak
- Book ID
- 117523017
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 298 KB
- Volume
- 211
- Category
- Article
- ISSN
- 0378-1119
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π SIMILAR VOLUMES
Chromosomal translocations are found to be a characteristic feature of Burkitt lymphomas. Similar translocations are found in mouse plasmacytomas and both diseases involve interchanges between one of the immunoglobulin loci and DNA in the vicinity of the myc gene. The structure of the myc gene has b
Although the Myc family of transcription factors is upregulated in many human tumors, it is unclear which genes are targets for the deregulated Myc. Previous studies suggest that hamster and rat carbamoyl phosphate synthase, aspartate transcarbamylase, dihydroorotase Cad genes are regulated by c-Myc