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Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC)

✍ Scribed by Blessmann, Marco; Al-Dam, Ahmed; Hanken, Henning; Assaf, Alexandre T.; Riecke, Björn; Klatt, Jan; Simon, Ronald; Sauter, Guido; Heiland, Max; Kluwe, Lan; Gröbe, Alexander

Book ID
123397823
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
587 KB
Volume
41
Category
Article
ISSN
1010-5182

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We previously proposed that a local duplication, not the loss of the subsequently amplified marker from its original site, might be the first step in gene amplification in human cells. It is important t o investigate this issue in naturally occurring amplification and when copy numbers are relativel