155 Clinical significance of the expression and amplification of the cortactin gene at 11q13 in head and neck squamous cell carcinomas
✍ Scribed by G. Alvarez Alija; S.T. Menéndez; D. García-Carracedo; E. Allonca; G. Mancebo; C. Suárez; J.P. Rodrigo; J.M. García-Pedrero
- Book ID
- 119601944
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 45 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1359-6349
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The presence of gene amplification was determined in 66 fresh head-and-neck SCC specimens using a battery of 9 different probes. Amplification of at least one gene was found in I 2 samples (18%), of which 7 were amplified at multiple loci (58%). We observed amplifications for EGFR (10% of samples) a
## Abstract Chromosomal amplifications of the 11q13 genomic region are frequent in head and neck squamous cell carcinoma (HNSCC). To identify novel 11q13 amplification targets, we integrated high‐resolution array‐based comparative genomic hybridization and Affymetrix gene‐expression profiling of ei