Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations
โ Scribed by Yu, Qiong; Li, Yan; Mu, Kun; Li, Zhishuang; Meng, Qingyong; Wu, Xiaojuan; Wang, Yan; Li, Li
- Book ID
- 125402450
- Publisher
- BioMed Central
- Year
- 2014
- Tongue
- English
- Weight
- 676 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1746-1596
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Inactivation of wild-type p53 during gastric carcinogenesis is usually caused by mutations within exons 5-8 of the p53 gene leading to mutated, usually immunohistochemically detectable p53 proteins. However, functional inactivation of wild-type p53, mimicking mutational inactivation, may also result
## Abstract Esophageal carcinomas from 24 patients, most of whom were smokers and consumed alcoholic beverages daily, were analyzed for mutations in exons 5โ8 of the __p53__ tumor suppressor gene. Mutations were identified by polymerase chain reaction amplification and direct sequencing in 12 of 24