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No evidence for functional inactivation of wild-type p53 protein by MDM-2 overexpression in gastric carcinogenesis: an immunohistochemical study

โœ Scribed by M.E. Craanen; P. Blok; W. Dekker; G.J.A. Offerhaus; G.N.J. Tytgat

Book ID
116121143
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
132 KB
Volume
47
Category
Article
ISSN
0300-2977

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No evidence for functional inactivation
No evidence for functional inactivation of wild-type p53 protein by MDM2 overexpression in gastric carcinogenesis
โœ Blok, P.; Craanen, M. E.; Dekker, W.; Offerhaus, G. J. A.; Tytgat, G. N. J. ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 244 KB ๐Ÿ‘ 1 views

Inactivation of wild-type p53 during gastric carcinogenesis is usually caused by mutations within exons 5-8 of the p53 gene leading to mutated, usually immunohistochemically detectable p53 proteins. However, functional inactivation of wild-type p53, mimicking mutational inactivation, may also result