Characterization of topoisomerase IIα ge
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Tero A.H. Järvinen; Minna Tanner; Maarit Bärlund; Åke Borg; Jorma Isola
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Article
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1999
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John Wiley and Sons
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English
⚖ 311 KB
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Topoisomerase II␣ (TOP2A) is a key enzyme in DNA replication and a molecular target for many important anticancer drugs. TOP2A is amplified or deleted together with amplification of the closely located ERBB2/HER-2/neu oncogene in breast cancer. We characterized the copy number aberrations of TOP2A a