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Amphiphilic Polymer Nanoparticles: Characterization and Assessment as New Drug Carriers

✍ Scribed by Pranabesh Dutta; Saurabh Shrivastava; Joykrishna Dey

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
446 KB
Volume
9
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

An amino‐acid‐based hydrophobically modified biocompatible copolymer, poly[(sodium N‐acryloyl‐L‐valinate)‐co‐(N‐octylacrylamide)] was synthesized and characterized. Techniques such as fluorescence probes, DLS, and TEM were used to investigate its aggregation behavior in aqueous solution. The copolymer was observed to form micellar aggregates having diameters in the nanometer range in aqueous solution (pH = 8) through inter‐chain hydrophobic association. This behavior was found to be similar to that of poly[(sodium N‐acryloyl‐L‐valinate)‐co‐(N‐dodecylacrylamide)]. The compact micellar nanostructures were observed to be stable with respect to changes of pH and temperature. The encapsulation and release of griseofulvin, a hydrophobic model drug, was studied.

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## Abstract Linking PEG~2,000~ polymers ending in 1 or 2 carboxylic groups to lipoamino acids (LAAs) gives mono‐ and homo‐disubstituted PEG‐LAA conjugates. They show an identical solubility to parent PEGs in water and organic solvents. By DSC the degree and depth of interaction of these conjugates