New Amphiphilic Conjugates of Mono- and Bis(carboxy)-PEG2,000 Polymers with Lipoamino Acids as Surface Modifiers of Colloidal Drug Carriers
✍ Scribed by Rosario Pignatello; Valentina Pantò; Livia Basile; Giuseppe Impallomeni; Alberto Ballistreri; Venerando Pistarà; Emanuela F. Craparo; Giovanni Puglisi
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 477 KB
- Volume
- 211
- Category
- Article
- ISSN
- 1022-1352
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✦ Synopsis
Abstract
Linking PEG~2,000~ polymers ending in 1 or 2 carboxylic groups to lipoamino acids (LAAs) gives mono‐ and homo‐disubstituted PEG‐LAA conjugates. They show an identical solubility to parent PEGs in water and organic solvents. By DSC the degree and depth of interaction of these conjugates with a biomembrane model is studied, gaining information about their future incorporation in drug‐loaded nanocarriers. The ability of PEG‐LAA conjugates to adopt an ordinate arrangement on the surface of particles and efficiently cover them is demonstrated, compared to DSPE‐PEG, by measuring the zeta potential values of negatively charged liposomes prepared in their presence.
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