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Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors

โœ Scribed by Kovar, Heinrich; Jug, Gunhild; Aryee, Dave NT; Zoubek, Andreas; Ambros, Peter; Gruber, Bernadette; Windhager, Reinhard; Gadner, Helmut

Book ID
110060977
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
492 KB
Volume
15
Category
Article
ISSN
0950-9232

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Selective induction of cell cycle regula
Selective induction of cell cycle regulatory genes cdk1 (p34cdc2), cyclins a/b, and the tumor suppressor gene RB in transformed cells by okadaic acid
โœ Jinsong You; R. Curtis Bird ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 962 KB

Genes encoding cdkl (~34'~''), cyclin A, cyclin B, and the tumor suppressor gene Rb are fundamental regulators of cell cycle progression which associate as a complex with the transcription factor E2F. Expression of many of these proteins has previously been shown to be repressed by okadaic acid, a s