Amino Acids and Peptides; 67. 1 Easy Preparation and Use of Benzyloxycarbonyl Derivatives of Amino Acid Chlorides and α-Hydroxycarboxylic Acid Chlorides
✍ Scribed by Schmidt, Ulrich; Kroner, Matthias; Beutler, Ulrich
- Book ID
- 121696901
- Publisher
- Thieme Medical Publishers
- Year
- 1988
- Tongue
- German
- Weight
- 197 KB
- Volume
- 1988
- Category
- Article
- ISSN
- 0039-7881
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📜 SIMILAR VOLUMES
The synthesis of peptides containing multiple Aib residues was accomplished using Fmoc-Aib-CI in presence of KOBt. As no additional base was added, the duration of coupling reactions could he extended. Thus, the synthesis of the alamethicin 1-4 fragment, Aib-Pro-Aib-Ala, the emerimicin 2-6 fragment,
Coupling of Frnoc-amino acid chlorides mediated by activated commercial zinc dust for the synthesis of peptides is described. The reaction is carried out in an organic medium. The necessity of using an inorganic base like NaHCO3/Na2CO3 or an organic base like DIEA/NMM/TEA/pyridine is circumvented. T