Amino acid sensing and regulation of mTORC1
β Scribed by Yan, Lijun; Lamb, Richard F.
- Book ID
- 118030125
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 232 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1084-9521
No coin nor oath required. For personal study only.
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## Abstract Numerous studies have shown that mammalian target of rapamycin (mTOR) inhibitor activates Akt signaling pathway via a negative feedback loop while inhibiting mTORC1 signaling. In this report, we focused on studying the role of mTORC1 and mTORC2 in rapamycinβmediated Akt and ERK phosphor