Regulation of amino acidβsensitive TOR s
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Christopher J. Lynch; Heather L. Fox; Thomas C. Vary; Leonard S. Jefferson; Scot
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Article
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2000
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John Wiley and Sons
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English
β 300 KB
In adipocytes, amino acids stimulate the target of rapamycin (TOR) signaling pathway leading to phosphorylation of the translational repressor, eIF-4E binding protein-I (4E-BP1), and ribosomal protein S6. L-leucine is the primary mediator of these effects. The structure-activity relationships of a p