𝔖 Bobbio Scriptorium
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Amidination of Lysine Side Chains

✍ Scribed by Dan S. Tawfik


Publisher
John Wiley and Sons
Year
2010
Weight
23 KB
Volume
33
Category
Article
ISSN
0931-7597

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The effect of lysine residues on the deamidation reaction of the asparagine side chain has been studied on the peptide Τ½ Τ½ Ac-Cys-Lys-Asn-Gly-Gln-Thr-Asn-Cys-NH 2 and on its lysine-acetylated derivative in a wide range of pH values. The amino acid sequence of these peptides is similar to the local s

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The biotin-1,4-diaminobutane (Bio-Put), biotin-tryptophan (Bio-Trp) and biotin-3-methylindole (Bio-Sct) systems were investigated by means of Raman spectroscopy. The interaction with Put renders the polar resonance forms of Bio more stabilized. One group of Put is protonated by the COOH group of Bio