Ambient Ionization Mass Spectrometry in Life Sciences: Principles and Applications

✍ Scribed by Kei Zaitsu (editor)

• Publisher: Elsevier
• Year: 2019
• Tongue: English
• Leaves: 294
• Category: Library

✦ Synopsis

Ambient Ionization Mass Spectrometry in Life Sciences: Principles and Applications is a systematic introduction to this rapidly expanding area of study. Underlying principles of each technique are explained in detail, along with discussions on their applications across life science disciplines. Ambient ionization has recently emerged as one of the hottest and fastest growing topics in mass spectrometry, hence this book is not just for analysts and researchers who use and study mass spectrometry. This volume would be of interest to anyone who works in or studies analytical chemistry, omics sciences (including metabolomics), pharmacokinetics, forensic science or drug analysis.

✦ Table of Contents

Contents
Contributors
Preface
Acknowledgments
1. Introduction to ambient ionization mass spectrometry
1.1 Definition of ambient ionization and classification
1.2 Overview of ambient ionization methods
1.3 Objectives of this book and brief explanation of each chapter
References
2. Direct analysis in real time
2.1 Introduction
2.2 DART ion source
2.3 Ionization processes in DART
2.4 Technical applications for improving DART performance/sensitivity
2.5 Applications using argon gas: atmospheric pressure dark current argon discharge ionization with comparable performance of he
References
3. Desorption corona beam ionization
3.1 Introduction
3.2 Principles of DCBI
3.3 Features of DCBI
3.4 Applications of DCBI
3.5 Summary
References
4. DESI-based imaging mass spectrometry in forensic science
4.1 Principle of DESI
4.2 Application I: forensic science
4.3 Application II: metabolite imaging for clinical diagnosis
4.4 Application III: reactive DESI
4.5 Conclusion and perspective
References
5. Ambient laser-based mass spectrometry analysis methods
5.1 Introduction
5.2 ELDI-MS
5.3 LAESI-MS
5.4 IR-MALDESI-MS
5.5 IR-LADESI-MS
5.6 LDSPI-MS
5.7 AIRLAB-MS
5.8 LEMS
5.9 AP-fsLDI-MS
5.10 LA-FAPA-MS
5.11 LA-APCI-MS
5.12 PAMLDI-MS
5.13 LIAD-ESI-MS
5.14 LIAD-APCI-MS
5.15 LIAD-APPI-MS
5.16 PIR-LAESI-MS
5.17 PIRL-MS
5.18 SpiderMass
References
6. Probe electrospray ionization/mass spectrometry and
6.1 Principle of probe electrospray ionization and the development of instruments
6.2 Applications of PESI to life sciences
ACKNOWLEDGMENTS
References
7. Design and construction of paper-spray ionization/mass
7.1 Introduction
7.2 Paper spray ionization/mass spectrometry
7.3 Modifications
7.4 Applications
7.5 Future perspectives
References
8. Rapid evaporative ionization mass spectrometry
8.1 Introduction
8.2 REIMS instrumentation
8.3 REIMS spectra and data handling
8.4 Applications
8.5 Summary
References
Index