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Ambient Eberlin reactions via desorption electrospray ionization mass spectrometry

✍ Scribed by Regina Sparrapan; Lívia S. Eberlin; Renato Haddad; R. Graham Cooks; Marcos N. Eberlin; Rodinei Augusti

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
177 KB
Volume
41
Category
Article
ISSN
1076-5174

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✦ Synopsis

Ambient Eberlin reactions via desorption electrospray ionization mass spectrometry

Mass spectrometry has become an essential technique in many branches of science. Its very broad range of applications results mainly from the introduction of a powerful set of techniques that have revolutionized the ionization process, which is the sine qua non condition for MS analysis. Recently, Cooks et al. 1 -3 introduced a new ionization technique: desorption electrospray ionization (DESI). This innovative approach allows the direct in situ ionization of chemicals placed on surfaces under ambient conditions. For DESI, the surface containing the analyte is exposed to electrosprayed charged droplets carried in a very high-velocity gas stream. The analyte is ionized and desorbed into the gas phase and then transferred to the mass spectrometer by electrostatic and pneumatic means. 4 Several applications of DESI-MS have now appeared, such as its use in direct examination of biological tissues, 5 on-spot MS analysis 6 for thin-layer chromatography 7 and trace level ambient detection of explosives. 8 In vacuo ion/molecule reactions, that is, those performed in the low pressure, very dilute environment of the mass spectrometer, are powerful tools in chemistry since they provide access to key properties and intrinsic reactivities of a great variety of solvent-and

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