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Alzheimer's disease: β-amyloid precursor protein mRNA expression in mononuclear blood cells

✍ Scribed by Allen, John S.; Murphy, Greer M.; Eng, Lawrence F.; Stultz, Karen E.; Davies, Helen D.; Pickford, Lesley B.; Tinklenberg, Jared R.

Book ID: 123515281
Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 407 KB
Volume: 132
Category: Article
ISSN: 0304-3940
DOI: 10.1016/0304-3940(91)90445-Y

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One of the pathological lesions in Alzheimer's disease (AD) is the amyloid or senile plaque. The plaque core is predominantly made up of amyloid beta peptide (AP), a 42-43 amino acid peptide derived from amyloid precursor protein (APP). APP is a membrane bound glycoprotein which is expressed ubiquit