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Alzheimer disease: presenilin springs a leak

✍ Scribed by Gandy, Sam; Doeven, Mark K; Poolman, Bert


Book ID
109931436
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
227 KB
Volume
12
Category
Article
ISSN
1078-8956

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The presenilins (PS-1 and PS-2) are 2 members of a novel family of genes encoding integral membrane proteins recently implicated in Alzheimer's disease (AD) pathology. To date, 43 mutations have been identified in PS-1 and 2 in PS-2 that lead to familial presenile AD (onset before age 65 years). The

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