Presenilin mutations in Alzheimer's dise
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Marc Cruts; Christine Van Broeckhoven
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Article
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1998
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John Wiley and Sons
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English
β 212 KB
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The presenilins (PS-1 and PS-2) are 2 members of a novel family of genes encoding integral membrane proteins recently implicated in Alzheimer's disease (AD) pathology. To date, 43 mutations have been identified in PS-1 and 2 in PS-2 that lead to familial presenile AD (onset before age 65 years). The