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Aluminum lons stimulate DNA synthesis in quiescent cultures of Swiss 3T3 and 3T6 cells

✍ Scribed by Jeffrey Bingham Smith

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
634 KB
Volume
118
Category
Article
ISSN
0021-9541

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✦ Synopsis

Micromolar concentrations of AI3+ are shown to be strongly mitogenic for quiescent cultures of Swiss 3T3 and 3T6 cells. AI3+ caused a striking shift in the dose-response curve for the effect of fetal bovine serum on 3H-thymidine incorporation. In the absence of serum the mitogenic effect of aluminum was greatly potentiated by insulin or cholera toxin, but not epidermal growth factor or 12-0-tetradecanoyl-phorbol-13-acetate. The stimulation of DNA synthesis was maximal by 15-20 microM AI3+ X AI3+ at 100 microM had no inhibitory effect on DNA synthesis. AI3+ had no significant effect on cellular cyclic adenosine monophosphate in the presence or absence of insulin or an inhibitor of cyclic nucleotide phosphodiesterases.

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