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Alternatives to amino acid analysis for the purity control of pharmaceutical grade L-alanine

✍ Scribed by Ulrike Holzgrabe; Cees-Jan Nap; Tanja Beyer; Stefan Almeling

Book ID: 102441620
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 305 KB
Volume: 33
Category: Article
ISSN: 1615-9306
DOI: 10.1002/jssc.201000141

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The quality control of drugs is important for safety of patients and consumers. International pharmacopoeias mostly employed HPLC with UV detection for this purpose. This is always a problem when the drugs, such as most amino acids, are lacking a chromophor. Instead of UV detection, the impurity control of alanine was performed using charged aerosol detector, evaporative light‐scattering detector, nano quantity analyte detector, MS detector, and as an orthogonal method, quantitative NMR spectroscopy. The charged aerosol detector, MS detector, and quantitative NMR spectroscopy provided similar and precise results, whereas the evaporative light‐scattering detector and nano quantity analyte detector revealed some problems regarding sensitivity, linearity, and robustness.

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