𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Alternative T cell receptor gene usage induced by self tolerance

✍ Scribed by Bernard Frangoulis; Marika Pla; Hans-Georg Rammensee

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
302 KB
Volume
19
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Alternative T cell receptor gene usage induced by self tolerance

Ab-restricted, H-Y-specific T cell clones from C57BU6 mice were found to use predominantly Vg6 T cell receptor genes, conferring Mls-la reactivity. However, the expression of Mls-la as a self antigen in (DBN2 X C57BU6)F1 mice did not turn these mice into nonresponders to H-Y. Instead of Vg6, they used other T cell receptor genes in this response. Thus, self tolerance appears to bias the repertoire of T cell receptor genes used in response to foreign antigens, without necessarily impairing the immune responsiveness to these antigens.

📜 SIMILAR VOLUMES

T-cell receptor Vβ gene usage by T cells
T-cell receptor Vβ gene usage by T cells reactive with the tumor-rejection antigen SART-1 in oral squamous cell carcinoma
✍ Wataru Kumamaru; Seiji Nakamura; Tsutomu Kadena; Akira Yamada; Eiji Kawamura; Ma 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 425 KB

## Abstract We recently described that the SART‐1~690–698~ peptide could induce HLA‐A24‐restricted cytotoxic T lymphocytes (CTLs), which recognize the SART‐1 tumor cells from peripheral blood mononuclear cells (PBMCs) of HLA‐A24^+^ cancer patients. In our study, in 5 of 14 HLA‐A24^+^ patients with

Analysis of T cell receptor Vβ gene usag
Analysis of T cell receptor Vβ gene usage in primary mixed lymphocyte reactions : evidence for directive usage by different antigen-presenting cells and Mls-like determinants on T cell blasts
✍ Eva-lotta Larsson-sciard; Anna-lena Spetz-hagberg; Armanda Casrouge; Philippe Ko 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 680 KB

## Analysis of T cell receptor Vp gene usage in primary mixed lymphocyte reactions : evidence for directive usage by different antigen-presenting cells and Mls-like determinants on T cell blasts The usage of four different Tcell receptor (TcR) Vp gene families within normal, non-primed Tcell popul

RESTRICTED USAGE OF T-CELL RECEPTOR Vα G
RESTRICTED USAGE OF T-CELL RECEPTOR Vα GENES IN INFILTRATING CELLS IN MURINE HEARTS WITH ACUTE MYOCARDITIS CAUSED BY COXSACKIE VIRUS B3
✍ SEKO, YOSHINORI; YOSHIFUMI, ENOKAWA; YAGITA, HIDEO; OKUMURA, KO; YAZAKI, YOSHIO 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 493 KB

In murine myocarditis, it has been shown that natural killer cells first infiltrate the heart, followed by activated T-cells, which play an important role in the pathogenesis of the myocardial damage. In the same model of acute myocarditis, the repertoire of T-cell receptor (TCR) V p genes in infilt

Delineation of the minimal encephalitoge
Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse Vβ gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor Vβb and T cell receptor Vβa H-2b mice
✍ Itzhak Mendel; Nicole Kerlero de Rosbo; Avraham Ben-Nun 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 926 KB

The nature of the autoimmune T cell response to myelin oligodendrocyte glycoprotein (MOG), recently recognized as a potential target antigen in multiple sclerosis (MS), has not yet been characterized, in contrast to theT cell reactivity to other potential target antigens in MS such as myelin basic p