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Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Rα) in peripheral blood from patients with multiple sclerosis (MS)

✍ Scribed by Lalit Rane; Nalini Vudattu; Kasia Bourcier; Eva Graniar; Jan Hillert; Vicki Seyfert; M J Maeurer


Book ID
113730628
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
744 KB
Volume
222
Category
Article
ISSN
0165-5728

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## Abstract Interleukin‐7‐receptor‐signaling plays a pivotal role in T‐cell development and maintenance of T‐cell memory. We studied IL‐7Rα (CD127) expression in PBMCs obtained from patients with breast cancer and examined IL‐7 receptor‐mediated downstream effects defined by STAT5 phosphorylation (