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Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis

✍ Scribed by Gregory, Simon G; Schmidt, Silke; Seth, Puneet; Oksenberg, Jorge R; Hart, John; Prokop, Angela; Caillier, Stacy J; Ban, Maria; Goris, An; Barcellos, Lisa F


Book ID
109919618
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
320 KB
Volume
39
Category
Article
ISSN
1061-4036

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✍ Ashok R. Venkitaraman; Rachel J. Cowling 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 856 KB

## Abstract The recently characterized receptor for interleukin (IL)‐7 (IL‐7R) includes a unique α chain as well as a common γ chain shared with the receptors for IL‐2 and IL‐4. Engagement of the IL‐7R activates the intracellular enzyme phosphatidylinositol (PtdIns) 3‐kinase but the mechanism of Pt