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Alternative splicing of DNA polymerase β mRNA is not tumor-specific

✍ Scribed by Radoslawa Nowak; Pawel Bieganowski; Ryszard Konopiński; Janusz A. Siedlecki

Book ID: 101233888
Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 446 KB
Volume: 68
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19961009)68:2<199::aid-ijc10>3.0.co;2-6

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✦ Synopsis

Mammalian DNA polymerase p is a crucial enzyme in cell genomic maintenance. Its structure is highly conserved. Some splice variants of p-pol mRNA were observed. One alternative splice DNA polymerase f3 mRNA, generated by 87 nt deletion (exon I I) in the catalytic domain of this enzyme, was suggested to be responsible for genomic instability in tumorigenesis and in genetic disorder (Werner syndrome). Here, we show that exon-I I -deleted p-pol mRNA is present in all examined normal

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