Alternative molecularly imprinted membranes from a derivative of natural polymer, cellulose acetate

✍ Scribed by Masakazu Yoshikawa; Takashi Ooi; Jun-Ichiro Izumi

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 195 KB
• Volume: 72
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/(sici)1097-4628(19990425)72:4<493::aid-app5>3.0.co;2-u

✦ Synopsis

Molecularly imprinted polymeric membranes were prepared from cellulose acetate (CA), of which acetyl content was 40%, by applying the alternative molecular imprinting technique. The Z-D-Glu imprinted polymeric membranes thus obtained recognized D-Glu in preference to L-Glu from racemic Glu mixtures and vice versa. The affinity constants between Glu and the chiral recognition site for two kinds of membranes were determined to be 3.1 ϫ 10 3 mol Ϫ1 dm 3 from the adsorption isotherm of D-Glu or L-Glu in the molecularly imprinted CA membranes. Enantioselective electrodialysis was attained with the present membranes reflecting their adsorption selectivity. D-Glu was preferentially permeated through the Z-D-Glu imprinted CA membrane, whereas L-Glu was permeated through the Z-L-Glu imprinted CA membrane. The present study suggests that the molecularly imprinted CA membranes are applicable to the optical resolution of racemic amino acids.