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Alternative modes of binding of proteins with tandem SH2 domains

โœ Scribed by Ronan O'Brien; Debora Renzoni; Michael D. Waterfield; Paul C. Driscoll; John E. Ladbury; Raj Handa; Kate Hilyard; Paul Rugman; Meredith Layto


Book ID
111753776
Publisher
Cold Spring Harbor Laboratory Press
Year
2008
Tongue
English
Weight
356 KB
Volume
9
Category
Article
ISSN
0961-8368

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Covalent binding of catechols to src fam
โœ Christopher T. Jagoe; Scott E. Kreifels; Jongming Li ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 192 KB

Src family SH2 domains contain an uncoupled cysteine residue, that, when arylated with air oxidized catechols, inhibits the protein from binding to otherwise high affinity peptide ligands. No inhibition is observed for Crk, Abl, or Grb2 SH2 domains.